The crash occurred east of Revelstoke, and the route had been closed for about 7 hours — but reopened just after 4:30.
The victim was driving a semi that was hit by an oncoming semi and caught fire.
A third semi and an SUV were also involved, with two people suffering serious injuries.
UPDATE: 11:30 a.m.
A multi-vehicle collision has closed the Trans Canada Highway in both directions between Revelstoke and Golden.
RCMP are telling people caught in the lineups that the #1 will not be re-opened again until at least 7 p.m. tonight.
There is no word yet on the extent of injuries to those involved or how many peope have been injured, but there crash is very serious in nature.
Check Drive BC for the latest updates.